We study the regulation and alternative splicing of gene expression in multiple tissues from human brains.
This dataset currently comprises of 134 brains from individuals free of neurodegenerative disorders. Up to twelve brain regions were extracted per brain in parallel for mRNA quantification. DNA was also collected to enable genotyping and expression quantitative trait loci (eQTL) analysis. See Materials & Methods for further details and funding sources.
Core Team Members
- Professor John Hardy,1
- Michael E Weale, 2
- Mina Ryten, 1
- Daniah Trabzuni, 1,3
- Adaikalavan Ramasamy, 2,1
- Colin Smith, 4
1 Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
2 Department of Medical and Molecular Genetics, King’s College London, 8th Floor, Tower Wing, Guy’s Hospital, London SE1 9RT, UK
3 Department of Genetics, King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia
4 Department of Neuropathology, MRC Sudden Death Brain Bank Project, University of Edinburgh, Wilkie Building, Teviot Place, Edinburgh EH8 9AG